Details

Autor(en) / Beteiligte

• Berardi, Alberto, MD
• Rossi, Cecilia, MD
• Creti, Roberta, PhD
• China, Mariachiara, MD
• Gherardi, Giovanni, PhD
• Venturelli, Claudia, MD
• Rumpianesi, Fabio, MD
• Ferrari, Fabrizio, MD

Titel

Group B Streptococcal Colonization in 160 Mother-Baby Pairs: A Prospective Cohort Study

Ist Teil von

• The Journal of pediatrics, 2013-10, Vol.163 (4), p.1099-1104.e1

Ort / Verlag

United States: Mosby, Inc

Erscheinungsjahr

2013

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Objectives To identify the source of postnatal colonization with group B Streptococcus (GBS) and to evaluate the impact of intrapartum antibiotic prophylaxis (IAP) administration in newborn infant transmission. Study design A prospective, longitudinal study evaluated GBS colonization in 160 mother-baby pairs. Specimens were collected from the time of delivery to 8 weeks post-partum, from rectum, vagina, and milk of mothers, and from throat and rectum of neonates. Women were grouped according to their GBS status at discharge from the hospital: culture-positive carriers (n = 83), culture-negative carriers (n = 26), and noncarriers (n = 51). Newborns were considered colonized if GBS was yielded from at least 1 site. Results A total of 35 (21.9%) neonates were colonized; 30 were born to culture-positive carriers, 2 to culture-negative carriers, and 3 to noncarriers. Infants of culture-positive carriers exposed to IAP were less likely to be colonized (15/57 vs 15/26, P  = .01), or heavily colonized, (7/57 vs 9/26, P  = .04). Of all newborns, those exposed to IAP and discharged GBS-free from hospital, often became colonized subsequently (12/57 vs 1/26, P  = .09). Molecular typing analysis (available for 30 of 32 carrier mothers and their infants) confirmed an identical strain of GBS in all mother-baby pairs. Six of 83 culture-positive carrier mothers had a positive milk culture. Their respective neonates all were heavily colonized. Conclusions Newborns exposed to IAP and GBS-free at hospital discharge subsequently acquire GBS from their mothers. Culture-positive milk is associated with heavy neonatal colonization.