Details

Autor(en) / Beteiligte

• Piao, Shu-Juan
• Song, Yun-Long
• Jiao, Wei-Hua
• Yang, Fan
• Liu, Xiang-Fang
• Chen, Wan-Sheng
• Han, Bing-Nan
• Lin, Hou-Wen

Titel

Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge Hippospongia lachne

Ist Teil von

• Organic letters, 2013-07, Vol.15 (14), p.3526-3529

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Hippolachnin A (1), a polyketide possessing an unprecedented carbon skeleton with a four-membered ring, was isolated from the South China Sea sponge Hippospongia lachne. The structure was elucidated using MS and NMR spectroscopic analyses, and the absolute configuration was determined using a calculated ECD method. Hippolachnin A demonstrated potent antifungal activity against three pathogenic fungi, Cryptococcus neoformans, Trichophyton rubrum, and Microsporum gypseum, with a MIC value of 0.41 μM for each fungus.