Details

Autor(en) / Beteiligte

• Coombes, J D
• Norris, D B
• Rising, T J
• Ross, B C
• Steward, A

Titel

In vitro histamine H sub(2)-antagonist activity of the novel compound HUK 978

Ist Teil von

• Life sciences (1973), 1985-01, Vol.37 (18), p.1711-1718

Erscheinungsjahr

1985

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Histamine stimulated adenylate cyclase from guinea-pig fundic mucosa and super(3)H-tiotidine binding in guinea-pig cerebral cortex were used to assess the in-vitro histamine H sub(2)-activity of the novel H sub(2)-antagonist HUK 978. The results showed that HUK 978 was a more potent H sub(2)-antagonist than either cimetidine or ranitidine. HUK 978 was also shown to be devoid of activity at the histamine H sub(1)-receptor, the muscarinic receptor and the alpha and beta -adrenergic receptors.