Details

Autor(en) / Beteiligte

• Doné, E.
• Gratacos, E.
• Nicolaides, K. H.
• Allegaert, K.
• Valencia, C.
• Castañon, M.
• Martinez, J.‐M.
• Jani, J.
• Van Mieghem, T.
• Greenough, A.
• Gomez, O.
• Lewi, P.
• Deprest, J.

Titel

Predictors of neonatal morbidity in fetuses with severe isolated congenital diaphragmatic hernia undergoing fetoscopic tracheal occlusion

Ist Teil von

• Ultrasound in obstetrics & gynecology, 2013-07, Vol.42 (1), p.77-83

Ort / Verlag

Chichester, UK: John Wiley & Sons, Ltd

Erscheinungsjahr

2013

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• ABSTRACT Objectives To investigate neonatal morbidity in fetuses with severe congenital diaphragmatic hernia (CDH) treated with fetoscopic endoluminal tracheal occlusion (FETO) and compare it with historical controls with less severe forms of CDH that were managed expectantly. Methods This was a prospective, multicenter study on neonatal outcomes and prenatal predictors in 90 FETO survivors (78 left‐sided, 12 right) and 41 controls from the antenatal CDH registry with either severe or moderate hypoplasia who were managed expectantly. We also investigated early neonatal morbidity indicators, including the need for patch repair, duration of mechanical ventilation and supplemental oxygen, age at full enteral feeding and incidence of pulmonary hypertension. Results Gestational age at delivery was predictive of duration of assisted ventilation (P = 0.046), days on supplemental oxygen (P = 0.019) and age at full enteral feeding (P = 0.020). When delivery took place after 34 weeks' gestation, neonatal morbidity of FETO cases was comparable with that of expectantly managed cases with moderate hypoplasia. Conclusions Fetal intervention for severe CDH is associated with neonatal morbidity that is comparable with that of an expectantly managed group with less severe disease. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.