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Predictors of neonatal morbidity in fetuses with severe isolated congenital diaphragmatic hernia undergoing fetoscopic tracheal occlusion
Ultrasound in obstetrics & gynecology, 2013-07, Vol.42 (1), p.77-83
Doné, E.
Gratacos, E.
Nicolaides, K. H.
Allegaert, K.
Valencia, C.
Castañon, M.
Martinez, J.‐M.
Jani, J.
Van Mieghem, T.
Greenough, A.
Gomez, O.
Lewi, P.
Deprest, J.
2013
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Doné, E.
Gratacos, E.
Nicolaides, K. H.
Allegaert, K.
Valencia, C.
Castañon, M.
Martinez, J.‐M.
Jani, J.
Van Mieghem, T.
Greenough, A.
Gomez, O.
Lewi, P.
Deprest, J.
Titel
Predictors of neonatal morbidity in fetuses with severe isolated congenital diaphragmatic hernia undergoing fetoscopic tracheal occlusion
Ist Teil von
Ultrasound in obstetrics & gynecology, 2013-07, Vol.42 (1), p.77-83
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2013
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
ABSTRACT Objectives To investigate neonatal morbidity in fetuses with severe congenital diaphragmatic hernia (CDH) treated with fetoscopic endoluminal tracheal occlusion (FETO) and compare it with historical controls with less severe forms of CDH that were managed expectantly. Methods This was a prospective, multicenter study on neonatal outcomes and prenatal predictors in 90 FETO survivors (78 left‐sided, 12 right) and 41 controls from the antenatal CDH registry with either severe or moderate hypoplasia who were managed expectantly. We also investigated early neonatal morbidity indicators, including the need for patch repair, duration of mechanical ventilation and supplemental oxygen, age at full enteral feeding and incidence of pulmonary hypertension. Results Gestational age at delivery was predictive of duration of assisted ventilation (P = 0.046), days on supplemental oxygen (P = 0.019) and age at full enteral feeding (P = 0.020). When delivery took place after 34 weeks' gestation, neonatal morbidity of FETO cases was comparable with that of expectantly managed cases with moderate hypoplasia. Conclusions Fetal intervention for severe CDH is associated with neonatal morbidity that is comparable with that of an expectantly managed group with less severe disease. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0960-7692
eISSN: 1469-0705
DOI: 10.1002/uog.12445
Titel-ID: cdi_proquest_miscellaneous_1434025938
Format
–
Schlagworte
Analysis of Variance
,
Balloon Occlusion - adverse effects
,
Belgium - epidemiology
,
congenital diaphragmatic hernia
,
England - epidemiology
,
Female
,
FETO
,
Fetoscopy - adverse effects
,
Gestational Age
,
Hernia, Diaphragmatic - embryology
,
Hernia, Diaphragmatic - mortality
,
Hernia, Diaphragmatic - physiopathology
,
Hernia, Diaphragmatic - surgery
,
Hernias, Diaphragmatic, Congenital
,
Humans
,
neonatal morbidity
,
Predictive Value of Tests
,
Pregnancy
,
Prospective Studies
,
pulmonary hypertension
,
pulmonary hypoplasia
,
Respiration, Artificial - methods
,
Respiration, Artificial - statistics & numerical data
,
Spain - epidemiology
,
Trachea
,
tracheal occlusion
,
Treatment Outcome
,
Ultrasonography, Doppler
,
Ultrasonography, Prenatal
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