Details

Autor(en) / Beteiligte

• Shi, Yongyong
• Zhao, Han
• Shi, Yuhua
• Cao, Yunxia
• Yang, Dongzi
• Li, Zhiqiang
• Zhang, Bo
• Liang, Xiaoyan
• Li, Tao
• Chen, Jianhua
• Shen, Jiawei
• Zhao, Junzhao
• You, Li
• Gao, Xuan
• Zhu, Dongyi
• Zhao, Xiaoming
• Yan, Ying
• Qin, Yingying
• Li, Wenjin
• Yan, Junhao
• Wang, Qingzhong
• Zhao, Junli
• Geng, Ling
• Ma, Jinlong
• Zhao, Yueran
• He, Guang
• Zhang, Aiping
• Zou, Shuhua
• Yang, Aijun
• Liu, Jiayin
• Li, Weidong
• Li, Baojie
• Wan, Chunling
• Qin, Ying
• Shi, Juanzi
• Yang, Jing
• Jiang, Hong
• Xu, Jin-e
• Qi, Xiujuan
• Sun, Yun
• Zhang, Yajie
• Hao, Cuifang
• Ju, Xiuqing
• Zhao, Dongni
• Ren, Chun-e
• Li, Xiuqing
• Zhang, Wei
• Zhang, Yiwen
• Zhang, Jiangtao
• Wu, Di
• Zhang, Changming
• He, Lin
• Chen, Zi-Jiang

Titel

Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome

Ist Teil von

• Nature genetics, 2012-09, Vol.44 (9), p.1020-1025

Ort / Verlag

New York: Nature Publishing Group US

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Zi-Jiang Chen and colleagues report a genome-wide association analysis for polycystic ovary syndrome (PCOS) in Han Chinese. They identify eight new susceptibility loci for PCOS in this population. Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510 polycystic ovary syndrome (PCOS) cases and 2,016 controls. We followed up significantly associated signals identified in the combined results of GWAS 1 and 2 in a total of 8,226 cases and 7,578 controls. In addition to confirming the three loci we previously reported, we identify eight new PCOS association signals at P < 5 × 10 −8 : 9q22.32, 11q22.1, 12q13.2, 12q14.3, 16q12.1, 19p13.3, 20q13.2 and a second independent signal at 2p16.3 (the FSHR gene). These PCOS association signals show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D). Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS.