Details

Autor(en) / Beteiligte

• Bianchi, Sara
• Giovannini, Stefania
• Zucchelli, Giancarlo
• Clerico, Aldo
• Pierini, Martina
• Ndreu, Rudina
• Vannucci, Alessandro
• Battaglia, Debora
• Vassalle, Cristina

Titel

Analysis of the 2010-2012 results of the multicenter external proficiency study for 25-hydroxyvitamin D

Ist Teil von

• Biomarkers in medicine, 2013-10, Vol.7 (5), p.691-699

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Results collected from the 2010-2012 cycles of the 'Immunocheck external quality assessment scheme for 25-hydroxyvitamin D, conducted by QualiMedLab CNR (Italy) and ProBioQual (France; 250 among Italian and French laboratories) are presented in this article. Details of how QualiMedLab operates can be found in QualiMedLab website. Interlaboratory imprecision was 19 (2010), 15 (2011) and 13% (2012). The LIAISON analyzer (DiaSorin, Italy) was the most utilized, followed by Roche (UK), ImmunoDiagnostic Systems methods (UK), ARCHITECT (Abbott, IL, USA), radioimmunoassay (DiaSorin) and others. The within-method variability between laboratories (percentage coefficient of variation) were 15, 12.7 versus 9.8% for LIAISON, 27.8, 16.5 versus 11.7% for Roche, 15, 12 versus 17% for ImmunoDiagnostic Systems and 17.4, 18.6 versus 17.5% for radioimmunoassay in the 2010, 2011 versus 2012 cycles, and 15 versus 8.9% for ARCHITECT in the 2011 versus 2012, respectively. Significant differences in specific samples and discrepancies between laboratories and methods still exist, making the actuation of appropriate external quality assessment schemes mandatory.