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Curcumin and liver disease
BioFactors (Oxford), 2013-01, Vol.39 (1), p.88-100
Vera-Ramirez, Laura
Pérez-Lopez, Patricia
Varela-Lopez, Alfonso
Ramirez-Tortosa, MCarmen
Battino, Maurizio
Quiles, José L.
2013
Details
Autor(en) / Beteiligte
Vera-Ramirez, Laura
Pérez-Lopez, Patricia
Varela-Lopez, Alfonso
Ramirez-Tortosa, MCarmen
Battino, Maurizio
Quiles, José L.
Titel
Curcumin and liver disease
Ist Teil von
BioFactors (Oxford), 2013-01, Vol.39 (1), p.88-100
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2013
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Liver diseases pose a major medical problem worldwide and a wide variety of herbs have been studied for the management of liver‐related diseases. In this respect, curcumin has long been used in traditional medicine, and in recent years it has been the object of increasing research interest. In combating liver diseases, it seems clear that curcumin exerts a hypolipidic effect, which prevents the fatty acid accumulation in the hepatocytes that may result from metabolic imbalances, and which may cause nonalcoholic steatohepatitis. Another crucial protective activity of curcumin, not only in the context of chronic liver diseases but also regarding carcinogenesis and other age‐related processes, is its potent antioxidant activity, which affects multiple processes and signaling pathways. The effects of curcumin on NF‐κβ are crucial to our understanding of the potent hepatoprotective role of this herb‐derived micronutrient. Because curcumin is a micronutrient that is closely related to cellular redox balance, its properties and activity give rise to a series of molecular reactions that in every case and biological situation affect the mitochondria. © 2013 BioFactors, 39(1):88–100, 2013
Sprache
Englisch
Identifikatoren
ISSN: 0951-6433
eISSN: 1872-8081
DOI: 10.1002/biof.1057
Titel-ID: cdi_proquest_miscellaneous_1434012987
Format
–
Schlagworte
Animals
,
Antioxidants - pharmacology
,
Antioxidants - therapeutic use
,
Apoptosis - drug effects
,
Cholestasis - drug therapy
,
Cholestasis - metabolism
,
cirrhosis
,
curcuma
,
Curcumin - pharmacology
,
Curcumin - therapeutic use
,
cytokines
,
Fatty Liver - drug therapy
,
Fatty Liver - metabolism
,
fibrosis
,
Hepatitis - drug therapy
,
Hepatitis - metabolism
,
hepatology
,
Humans
,
inflammation
,
Liver Cirrhosis - drug therapy
,
Liver Cirrhosis - metabolism
,
Liver Diseases - drug therapy
,
Liver Diseases - metabolism
,
Liver Neoplasms - drug therapy
,
Liver Neoplasms - metabolism
,
mitochondria
,
Non-alcoholic Fatty Liver Disease
,
nuclear factors
,
Oxidative Stress
,
steatohepatitis
,
steatosis
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