Details

Autor(en) / Beteiligte

• Lambein, Kathleen
• Van Bockstal, Mieke
• Vandemaele, Lies
• Geenen, Sofie
• Rottiers, Isabelle
• Nuyts, Ann
• Matthys, Bart
• Praet, Marleen
• Denys, Hannelore
• Libbrecht, Louis

Titel

Distinguishing score 0 from score 1+ in HER2 immunohistochemistry-negative breast cancer: clinical and pathobiological relevance

Ist Teil von

• American journal of clinical pathology, 2013-10, Vol.140 (4), p.561-566

Ort / Verlag

England

Erscheinungsjahr

2013

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• To investigate the clinical and pathobiological significance of distinguishing score 0 and score 1+ within the group of immunohistochemistry (IHC)-negative invasive breast cancers. We studied HER2 status using both IHC and fluorescence in situ hybridization (FISH) in 150 consecutive breast tumors submitted to our laboratory after a negative IHC result in local testing centers. We were able to discern a group of score 0 tumors that had a lower HER2 copy number than the group consisting of score 1+ tumors. In contrast with the group of score 1+ tumors, HER2 FISH was consistently negative for both copy number-based and ratio-based tumors without equivocal results. In a setting with stringent quality assurance, score 0 and score 1+ tumors emerge as distinct and clinically important subgroups within the HER2 IHC-negative population.