Details

Autor(en) / Beteiligte

• Alves, Christiano R. R.
• Santiago, Bianca M.
• Lima, Fernanda R.
• Otaduy, Maria C. G.
• Calich, Ana Luisa
• Tritto, Aline C. C.
• Sá Pinto, Ana Lúcia
• Roschel, Hamilton
• Leite, Cláudia C.
• Benatti, Fabiana B.
• Bonfá, Eloisa
• Gualano, Bruno

Titel

Creatine Supplementation in Fibromyalgia: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Ist Teil von

• Arthritis care & research (2010), 2013-09, Vol.65 (9), p.1449-1459

Ort / Verlag

United States

Erscheinungsjahr

2013

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Objective To investigate the efficacy and safety of creatine supplementation in fibromyalgia patients. Methods A 16‐week, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted. Fibromyalgia patients were randomly assigned to receive either creatine monohydrate or placebo in a double‐blind manner. The patients were evaluated at baseline and after 16 weeks. Muscle function, aerobic conditioning, cognitive function, quality of sleep, quality of life, kidney function, and adverse events were assessed. Muscle phosphorylcreatine content was measured through 31P magnetic resonance spectroscopy. Results After the intervention, the creatine group presented higher muscle phosphorylcreatine content when compared with the placebo group (+80.3% versus −2.7%; P = 0.04). Furthermore, the creatine group presented greater muscle strength than the placebo group in the leg press and chest press exercises (+9.8% and +1.2% for creatine versus −0.5% and −7.2% for placebo, respectively; P = 0.02 and P = 0.002, respectively). Isometric strength was greater in the creatine group than in the placebo group (+6.4% versus −3.2%; P = 0.007). However, no general changes were observed in aerobic conditioning, pain, cognitive function, quality of sleep, and quality of life. Food intake remained unaltered and no side effects were reported. Conclusion Creatine supplementation increased intramuscular phosphorylcreatine content and improved lower‐ and upper‐body muscle function, with minor changes in other fibromyalgia features. These findings introduce creatine supplementation as a useful dietary intervention to improve muscle function in fibromyalgia patients.