Details

Autor(en) / Beteiligte

• Breen, David J.
• Bryant, Timothy J.
• Abbas, Ausami
• Shepherd, Beth
• McGill, Neil
• Anderson, Jane A.
• Lockyer, Richard C.
• Hayes, Matthew C.
• George, Steve L.

Titel

Percutaneous cryoablation of renal tumours: outcomes from 171 tumours in 147 patients

Ist Teil von

• BJU international, 2013-10, Vol.112 (6), p.758-765

Ort / Verlag

Oxford: Wiley-Blackwell

Erscheinungsjahr

2013

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Objective To evaluate the technical and oncological efficacy of an image‐guided cryoablation programme for renal tumours. Patients and Methods A prospective analysis of technical and radiological outcomes was undertaken after treatment of 171 consecutive tumours in 147 patients. Oncological efficacy in a subset of 125 tumours in 104 patients with >6 months' radiological follow‐up and a further subset of 62 patients with solitary, biopsy‐proven renal carcinoma was also analysed. Factors influencing technical success, as determined by imaging follow‐up, and complication rates were statistically analysed using a statistics software package and logistic regression analyses. Results No variables were found to predict subtotal treatment, although gender (P = 0.08), tumour size of >4 cm (P = 0.09) and central location of tumour (P = 0.07) approached significance. Upper pole location was the single variable that was found to predict complications (P = 0.006). Among the 104 patients (125 tumours), radiologically assessed at ≥6 months and with a mean radiological follow‐up of 20.1 months, we found a single case of unexpected late local recurrence. Conclusion Percutaneous image‐guided cryoablation, at a mean of 20.1 months' follow‐up, appears to provide a safe and effective treatment option with a low complication rate. Anteriorly sited tumours should not be considered a contraindication for percutaneous image‐guided cryoablation.