Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Detection and Genotyping of Helicobacter pylori Gene vacA in Children with Gastroduodenal Diseases and in Adults with Gastric Cancer in Vladivostok
Ist Teil von
Bulletin of experimental biology and medicine, 2013-05, Vol.155 (1), p.85-88
Ort / Verlag
Boston: Springer US
Erscheinungsjahr
2013
Quelle
MEDLINE
Beschreibungen/Notizen
Geographical distribution of individual genotypes of
Helicobacter pylori
, predominance of virulent types in various regions of Russia, particularly in the Prymorye Territory, remains unclear. We examined 115 children with various gastroduodenal pathology and 33 patients with gastric cancer, of which 57.39 and 60% respectively were infected with
H. pylori
. All samples positive for
H. pylori
were further analyzed for gene
vacA
mosaicism. In all clinical subgroups, variants
s1
and
m1
predominated; the frequency of genotype
s1
was significantly increased (1.3-fold) in the group of cancer patients in comparison with the group of children with gastroduodenal pathology. Three variants of allele combination of signaling and middle regions of the
vacA
gene (
s1m1
,
s1m2
, and
s2m2
) were revealed;
s1m1
was the most frequent in both groups. We suggest that this genotype is a marker of complicated course of gastroduodenitis and a factor of gastric cancer development in local population.