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An attenuated temperature-sensitive strain of cytomegalovirus (tsm5) establishes immunity without development of CD8+ T cell memory inflation
Journal of medical virology, 2013-11, Vol.85 (11), p.1968-1974
Beswick, Mark
Pachnio, Annette
Al-Ali, Abdulaziz
Sweet, Clive
Moss, Paul A.
2013
Details
Autor(en) / Beteiligte
Beswick, Mark
Pachnio, Annette
Al-Ali, Abdulaziz
Sweet, Clive
Moss, Paul A.
Titel
An attenuated temperature-sensitive strain of cytomegalovirus (tsm5) establishes immunity without development of CD8+ T cell memory inflation
Ist Teil von
Journal of medical virology, 2013-11, Vol.85 (11), p.1968-1974
Ort / Verlag
Hoboken, NJ: Blackwell Publishing Ltd
Erscheinungsjahr
2013
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Cytomegalovirus (CMV) is a widely prevalent herpesvirus that is well tolerated by an immune competent host yet establishes a state of chronic infection. The virus is thought to undergo frequent subclinical episodes of reactivation which leads to an unusually large accumulation of CMV‐specific CD8+ T lymphocytes in the peripheral blood, a phenomenon termed “memory inflation.” The high magnitude of the CMV T cell response has been implicated in impaired immunity to heterologous pathogens such as EBV, influenza and West Nile virus. Here, using murine CMV (MCMV), we show that memory inflation of virus‐specific CD8+ T cells is avoided if mice are infected with a replication defective virus called temperature‐sensitive mutant 5 (tsm5), which carries an attenuating mutation within the DNA primase gene. Mice infected with tsm5 do generate primary T cell responses towards viral proteins but these do not amass to skew the memory repertoire of CD8+ T cells. Therefore, attenuation of the virus replication machinery may be valuable in future CMV vaccine designs because the virus remains immunogenic but does not contribute to CMV associated T cell immune senescence. J Med. Virol. 85:1968–1974, 2013. © 2013 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.23688
Titel-ID: cdi_proquest_miscellaneous_1428772111
Format
–
Schlagworte
Animals
,
Biological and medical sciences
,
CD8+ T lymphocyte
,
CD8-Positive T-Lymphocytes - immunology
,
cytomegalovirus (CMV)
,
Cytomegalovirus Vaccines - administration & dosage
,
Cytomegalovirus Vaccines - immunology
,
Disease Models, Animal
,
Female
,
Fundamental and applied biological sciences. Psychology
,
Herpesviridae Infections - immunology
,
Herpesviridae Infections - virology
,
Human viral diseases
,
Immunologic Memory
,
Infectious diseases
,
Medical sciences
,
memory inflation
,
Mice
,
Mice, Inbred C57BL
,
Microbiology
,
Miscellaneous
,
murine cytomegalovirus (MCMV)
,
Muromegalovirus - immunology
,
Muromegalovirus - physiology
,
Mutation
,
Vaccines, Attenuated - administration & dosage
,
Vaccines, Attenuated - immunology
,
Viral diseases
,
Virology
,
Virulence
,
Virus Replication
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