Histopathology, 2012-12, Vol.61 (6), p.1006-1016
2012
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- Autor(en) / Beteiligte
- Titel
- VEGF-C, VEGF-D and VEGFR-3 expression in peripheral neuroblastic tumours
- Ist Teil von
- Histopathology, 2012-12, Vol.61 (6), p.1006-1016
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Ramani P, Nash R, Radevsky L, Patel A, Luckett M & Rogers C (2012) Histopathology VEGF‐C, VEGF‐D and VEGFR‐3 expression in peripheral neuroblastic tumours Aims: More than 50% of neuroblastomas (NBs) present with haematogenous and/or lymphatic metastasis; however, little is known about the clinicopathological significance in NBs of the key lymphangiogenesis growth factors vascular endothelial growth factor (VEGF)‐C and VEGF‐D and the receptor VEGFR‐3. Methods and results: Ninety‐three NBs and nine ganglioneuromas (GNs) were immunostained for VEGF‐C, VEGF‐D and VEGFR‐3. VEGF‐C and VEGF‐D were present in 76% and 82% of the NBs, respectively. There was no significant difference in VEGF‐C expression between NBs and GNs. VEGF‐D expression was significantly higher in NBs compared with GNs and in MYCN‐amplified NBs. VEGFR‐3 tumoral cell expression (VEGFR‐3c), present in 48% of the NBs, was significantly higher in NBs from children ≥18 months at presentation and those belonging to a high‐risk group. VEGFR‐3 lymphovascular density was increased significantly in NBs compared with GNs and in NBs associated with adverse clinicopathological and biological factors. Lymphovascular invasion, assessed in VEGFR‐3‐stained vessels, was present in ∼50% of NBs. Cox regression analyses demonstrated that VEGFR‐3c expression was associated with a significantly shorter event‐free survival and that its effect was independent of the important pathological variable, mitosis–karyorrhexis index. Conclusions: VEGF‐D and VEGFR‐3 up‐regulation support tumour progression in NB and VEGFR‐3c may provide a useful prognostic marker in NBs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0309-0167eISSN: 1365-2559DOI: 10.1111/j.1365-2559.2012.04307.xTitel-ID: cdi_proquest_miscellaneous_1419364390
- Format
- –
- Schlagworte
- Adolescent, Biological and medical sciences, Biomarkers, Tumor - metabolism, Child, Child, Preschool, Disease Progression, ganglioneuroma, Ganglioneuroma - diagnosis, Ganglioneuroma - metabolism, Ganglioneuroma - mortality, Gene Expression Regulation, Neoplastic, Humans, immunohistochemistry, Infant, Infant, Newborn, Investigative techniques, diagnostic techniques (general aspects), Kaplan-Meier Estimate, Lymphangiogenesis - physiology, Lymphatic system, lymphovascular invasion, Medical sciences, neuroblastoma, Neuroblastoma - diagnosis, Neuroblastoma - metabolism, Neuroblastoma - mortality, Neurology, Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques, Peripheral Nervous System Neoplasms - diagnosis, Peripheral Nervous System Neoplasms - metabolism, Peripheral Nervous System Neoplasms - mortality, Prognosis, Proteins, Retrospective Studies, Tumors, Tumors of the nervous system. Phacomatoses, Up-Regulation, Vascular endothelial growth factor, Vascular Endothelial Growth Factor C - genetics, Vascular Endothelial Growth Factor C - metabolism, Vascular Endothelial Growth Factor D - genetics, Vascular Endothelial Growth Factor D - metabolism, Vascular Endothelial Growth Factor Receptor-3 - genetics, Vascular Endothelial Growth Factor Receptor-3 - metabolism, VEGF-C, VEGF-D, VEGFR-3