Details

Autor(en) / Beteiligte

• Hanssen, Nordin M. J
• Engelen, Lian
• Ferreira, Isabel
• Scheijen, Jean L. J. M
• Huijberts, Maya S
• van Greevenbroek, Marleen M. J
• van der Kallen, Carla J. H
• Dekker, Jacqueline M
• Nijpels, Giel
• Stehouwer, Coen D. A
• Schalkwijk, Casper G

Titel

Plasma Levels of Advanced Glycation Endproducts Nϵ-(carboxymethyl)lysine, Nϵ-(carboxyethyl)lysine, and Pentosidine Are not Independently Associated With Cardiovascular Disease in Individuals With or Without Type 2 Diabetes: The Hoorn and CODAM Studies

Ist Teil von

• The journal of clinical endocrinology and metabolism, 2013-08, Vol.98 (8), p.E1369-E1373

Ort / Verlag

United States: Endocrine Society

Erscheinungsjahr

2013

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Objective: Experimental and histological data suggest a role for advanced glycation end products (AGEs) in cardiovascular disease (CVD), particularly in type 2 diabetes (T2DM). However, the epidemiological evidence of an adverse association between AGEs and CVD remains inconclusive. We therefore investigated, in individuals with various degrees of glucose metabolism, the associations of plasma AGEs with prevalent CVD. Research Design and Methods: We measured plasma levels of protein-bound Nϵ-(carboxymethyl)lysine (CML), Nϵ-(carboxyethyl)lysine (CEL), and pentosidine, in participants from two Dutch cohort studies (n = 1291, mean age 64.7 ± 8.3 years, 45% women), including 573 individuals with normal glucose metabolism, 304 with impaired glucose metabolism, and 414 with T2DM. In addition, we measured free CML, CEL, and 5-hydro-5-methylimidazolone in a subset of participants (n = 554). Data were analyzed with multiple logistic or linear regression analyses. Results: CEL (32 [interquartile range: 25–40] vs 28 [22–35] nmol/mmol lysine) and pentosidine (0.53 [0.43–0.67] vs 0.48 [0.40–0.59] nmol/mmol lysine) as well as free CEL (48 [39–62] vs 45 [36–56] nmol/L) and 5-hydro-5-methylimidazolone (141 [96–209] vs 116 [84–165] nmol/L) were higher in individuals with vs without CVD, whereas protein-bound CML was lower (33 [27–38] vs 34 [29–39] nmol/mmol lysine). However, these differences disappeared after adjustment for confounders. The associations did not differ consistently between individuals with and without T2DM. Conclusions: We found no independent adverse associations of plasma AGEs with CVD in individuals with normal glucose metabolism, impaired glucose metabolism, and T2DM.