Journal of allergy and clinical immunology, 2013-08, Vol.132 (2), p.493-495
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives
- Ist Teil von
- Journal of allergy and clinical immunology, 2013-08, Vol.132 (2), p.493-495
- Ort / Verlag
- New York, NY: Mosby, Inc
- Erscheinungsjahr
- 2013
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Functional studies showing the rapid, processing independent activation of T cells by certain drugs supports this hypothesis.5 Recently, direct binding of the drugs abacavir and CBZ to specific HLA molecules has been shown to alter the peptide repertoire displayed on the surface of antigen-presenting cells,6 leading the authors to propose that endogenous peptides activate "drug"-specific T cells. [...]CBZ metabolite-derived protein adducts were not studied and the levels of CBZ metabolites formed in lymphocyte test systems is known to be extremely low and almost certainly below the limit of detection by conventional mass spectrometers. [...]we have developed an alternative strategy to explore whether CBZ-responsive T cells are activated via a metabolism-independent pathway.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0091-6749eISSN: 1097-6825DOI: 10.1016/j.jaci.2013.02.045Titel-ID: cdi_proquest_miscellaneous_1417533660
- Format
- –
- Schlagworte
- Allergy and Immunology, Biological and medical sciences, Carbamazepine - adverse effects, Carbamazepine - analogs & derivatives, Carbamazepine - immunology, Carbamazepine - metabolism, Cloning, Cytokines, Derivatives, Drug Hypersensitivity - etiology, Drug Hypersensitivity - immunology, Fluorine, Fundamental and applied biological sciences. Psychology, Fundamental immunology, Halogens - chemistry, Halogens - immunology, Halogens - metabolism, Humans, Hypersensitivity, Immediate - etiology, Hypersensitivity, Immediate - immunology, Hypotheses, Lymphocyte Activation - drug effects, Lymphocyte Activation - immunology, Lymphocytes, Medical sciences, Metabolism, Metabolites, Peptides, Proteins, Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis, T cell receptors, T-Lymphocytes - immunology