Trends in endocrinology and metabolism, 2013-08, Vol.24 (8), p.398-407
2013
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- Autor(en) / Beteiligte
- Titel
- The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?
- Ist Teil von
- Trends in endocrinology and metabolism, 2013-08, Vol.24 (8), p.398-407
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Activation of GPR40 by fatty acids potentiates glucose-induced insulin secretion. • GPR40 is not implicated in the toxic effects of chronic fatty acids on β-cells. • GPR40 couples to Gαq/11 , activation of protein kinase D1, and actin depolymerization. • The GPR40 agonist TAK-875 is a promising drug candidate for type 2 diabetes. • Our understanding of the biology and pharmacology of GPR40 remains incomplete.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1043-2760eISSN: 1879-3061DOI: 10.1016/j.tem.2013.03.003Titel-ID: cdi_proquest_miscellaneous_1417531784
- Format
- –
- Schlagworte
- Animals, biased agonism, Diabetes Mellitus, Type 2 - genetics, Diabetes Mellitus, Type 2 - metabolism, Endocrinology & Metabolism, GPR40/FFA1, Humans, Insulin - metabolism, insulin secretion, Insulin-Secreting Cells - metabolism, pancreatic β cell, Receptors, G-Protein-Coupled - genetics, Receptors, G-Protein-Coupled - metabolism, type 2 diabetes