Details

Autor(en) / Beteiligte

• Lin, Yiwei
• Chen, Hong
• Hu, Zhenghui
• Mao, Yeqing
• Xu, Xianglai
• Zhu, Yi
• Xu, Xin
• Wu, Jian
• Li, Shiqi
• Mao, Qiqi
• Zheng, Xiangyi
• Xie, Liping

Titel

miR-26a inhibits proliferation and motility in bladder cancer by targeting HMGA1

Ist Teil von

• FEBS letters, 2013-08, Vol.587 (15), p.2467-2473

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

2013

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• •miR-26a is down-regulated in bladder cancer tissue samples.•miR-26a inhibits bladder cancer cell T24 proliferation and motility.•HMGA1 is a direct target of miR-26a.•HMGA1 is frequently over-expressed in bladder cancer tissue.•HMGA1 can promote T24 cell cycle progression. It is increasingly clear that microRNAs play a crucial role in tumorigenesis. Recently, emerging evidence suggested that miR-26a is aberrantly expressed in tumor tissues. In our study, frequent down-regulation of miR-26a was observed in 10 human bladder cancer tissues. Forced expression of miR-26a in the bladder cancer cell line T24 inhibited cell proliferation and impaired cell motility. High mobility group AT-hook 1 (HMGA1), a gene that modulates cell cycle transition and cell motility, was verified as a novel target of miR-26a in bladder cancer. These findings indicate an important role for miR-26a in the molecular etiology of bladder cancer and implicate the potential application of miR-26a in bladder cancer therapy.