Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4622-4626
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Confirmation of quinolone-induced formation of gyrase–DNA conjugates using AFM
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4622-4626
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- It was demonstrated in our studies that norfloxacin, a representative member of quinolone antibiotics, can indeed stabilize the gyrase–DNA complex formed during enzymatic cycle. In addition, the formation of the drug-induced complex has been firstly visualized through our atomic force microscopic examination.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2013.06.021Titel-ID: cdi_proquest_miscellaneous_1412557440
- Format
- –
- Schlagworte
- AFM, Anti-Bacterial Agents - pharmacology, antibiotics, chemistry, Complexes, DNA Gyrase - metabolism, Electrophoresis, Agar Gel, Enzyme Stability - drug effects, Gyrase, microscopy, Microscopy, Atomic Force, Molecular Structure, Norfloxacin, Norfloxacin - pharmacology, Quinolines - pharmacology, Quinolone