Biochemical pharmacology, 1984-12, Vol.33 (24), p.4011-4015
1984
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Central side effects of pentamethylmelamine: Biochemical and behavioural studies
- Ist Teil von
- Biochemical pharmacology, 1984-12, Vol.33 (24), p.4011-4015
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 1984
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- The central side effects of pentamethylmelamine (PMM), an antitumoral agent, were studied on brain neurotransmitters from the biochemical and behavioural points of view. PMM causes a dose-related reduction in the body temperature and motility of mice. 100 mg/kg of PMM lowers the levels of noradrenaline (NA) and raises 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) in the telencephalon. A similar dose increased striatal levels of dopamine (DA) metabolites, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC), at earlier times (30 min), reducing their levels at 2 hr. These effects disappear at longer times (4 hr). No changes were observed in the levels of 3-methoxytyramine (3-MT), the extraneuronal metabolite of DA. The serotonin metabolite 5-hydroxyindolacetic acid (5HIAA) was almost not affected. PMM and its metabolites do not displace [ 3H]-spiroperidol from mouse striatal binding sites. These data show that some of the neurological effects induced by PMM are associated with changes in the metabolism and/or release of brain catecholamines but are not mediated by direct action on DA receptors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-2952eISSN: 1873-2968DOI: 10.1016/0006-2952(84)90014-5Titel-ID: cdi_proquest_miscellaneous_14121535
- Format
- –
- Schlagworte
- Altretamine - analogs & derivatives, Altretamine - toxicity, Animals, Biogenic Amines - metabolism, Biological and medical sciences, Body Temperature - drug effects, Brain - drug effects, Brain - metabolism, Dopamine - metabolism, Dose-Response Relationship, Drug, Drug toxicity and drugs side effects treatment, Female, Medical sciences, Mice, Mice, Inbred C57BL, Motor Activity - drug effects, Pharmacology. Drug treatments, Receptors, Dopamine - metabolism, Spiperone - metabolism, Toxicity: nervous system and muscle, Triazines - toxicity