Details

Autor(en) / Beteiligte

• Leyland-Jones, Brian

Titel

Erythropoiesis stimulating agents: a personal journey

Ist Teil von

• JNCI : Journal of the National Cancer Institute, 2013-07, Vol.105 (14), p.999-1001

Ort / Verlag

United States: Oxford Publishing Limited (England)

Erscheinungsjahr

2013

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Leylan-Jones talks about a personal journey of a medical oncologist who is desperately trying to improve the outcomes of women suffering from breast cancer. At the end of the l990s, there was much hope that erythropoiesis stimulating agents would improve the survival of cancer patients. It was all so very obvious. Elegant partial oxygen pressure (pO2) histograms showed differential oxygenation between normal and malignant tissues, and patients with higher tumoral pO2 were demonstrated to have improved survival. Beverly Teicher had shown the oxygen-dependency of cancer and had published oxygen enhancement ratios for the representative members of the key mechanistic classes of anticancer agents. Leylan-Jones says that with regard to disease progression, this seems to be the most controversial area.