Details

Autor(en) / Beteiligte

• Gerson, Myron C.
• Dwivedi, Alok K.
• Abdallah, Mouhamad
• Shukla, Rakesh
• Jacobson, Arnold F.

Titel

Significance of I-123 metaiodobenzylguanidine (123I-MIBG) lung activity in subjects with heart failure in comparison to healthy control subjects

Ist Teil von

• Journal of nuclear cardiology, 2013-08, Vol.20 (4), p.592-599

Ort / Verlag

Boston: Elsevier Inc

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Little is known concerning the significance of lung activity of the sympathetic neuronal imaging agent 123I-MIBG in heart failure patients and healthy subjects. 123I-MIBG activity was assessed in lung, heart, and mediastinum regions of interest on early and late planar images in 951 heart failure patients and 94 controls. Cox regression analyses were performed to identify factors associated with outcome events during a median 17 month follow-up. Heart failure subjects with pulmonary disease had significantly reduced late lung-to-mediastinum (L/M) ratios compared to heart failure subjects without pulmonary disease. Late L/M ratio was greater in heart failure subjects without outcome events than either subjects with events or healthy controls. L/M ratio was an independent predictor of all-cause mortality. Subjects with combined favorable prognosis L/M ratio ≥ 1.7 and heart-to-mediastinum ratio (H/M) ≥ 1.6 had a significantly lower 2-year mortality (2.0%) than subjects with unfavorable L/M ratio < 1.7 and H/M ratio < 1.6 (17.7% 2-year mortality, P < .0008). Increased 123I-MIBG lung activity in heart failure subjects, compared to controls, is associated with a relatively low risk of adverse events, including all-cause mortality. L/M ratio may, therefore, be useful to provide incremental prognostic information on 123I-MIBG imaging.