Details

Autor(en) / Beteiligte

• Geard, C R
• Shea, C M
• Georgasson, MA

Titel

Paraquat and radiation effects on mouse C sub(3)H 10T1/2 Cells

Ist Teil von

• International journal of radiation oncology, biology, physics, 1984-01, Vol.10 (8), p.1407-1410

Erscheinungsjahr

1984

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The dipyridilium compound, paraquat, has been used in conjunction with mouse C sub(3)H 10T1/2 cells to determine if this superoxide (O sub(2) super(-)) generating agent acts to oncogenically transform, chromosomally alter or influence cytokinetics or cellular survival. Paraquat alone is a cytotoxic agent and is additionally a weak radiosensitizer. It is a poor inducer of SCE's and combined effects with radiation are strictly additive. Paraquat oncogenically transforms cells but not in a dose-dependent manner, yet combined treatments with 3 Gy result in transformation frequencies greater than expected for additive effects. Depending on the endpoint examined, which may be related to the degree of nuclear involvement, paraquat either acts additively (SCE's) or with greater than an additive effect (cell survival and oncogenic transformation).