Details

Autor(en) / Beteiligte

• Kastl, P.E.
• Hermann, E.A.

Titel

Quantitative gas chromatographic determination of hexachloro-1,3-butadiene in whole rat blood at part per trillion levels

Ist Teil von

• Journal of Chromatography A, 1983-01, Vol.280 (2), p.390-393

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

1983

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• 1,1,2,3,4,4-Hexachloro-1,3-butadiene, (HCBD), is a colorless liquid industrial by-product found in the manufacturing of chlorinated hydrocarbons. The toxicity associated with chronic exposure of laboratory rats has been reported. In order to assess the pharmacokinetics of HCBD administered to rats an analytical method was required to dertermine low level concentrations of HCBD in whole rat blood. This paper describes a simple gas chromatographic (GC) method for the determination of HCBD in whole rat blood at part per trillion levels.