Details

Autor(en) / Beteiligte

• Sanger, W G
• Howe, J
• dyce, R
• Purtilo, D T

Titel

Inherited partial trisomy No. 15 complicated by neuroblastoma

Ist Teil von

• Cancer genetics and cytogenetics, 1984-01, Vol.11 (2), p.153-160

Erscheinungsjahr

1984

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The proband in this study had multiple congenital malformations and a constitutional 46,XY, -13, + der(13),t(13; 15)(q34; q23)mat chromosome complement. A bone marrow aspirate revealed neuroblastoma, and cytogenetic studies on tumor cells revealed, in addition to the partial trisomy No. 15 and probable partial monosomy No. 13, hypotetraploidy with a mean chromosome number of 82-84, including 3 or 4 copies of each autosome, 2 X chromosomes, no Y chromosome, and a marker. Translocations involving chromosomes No. 1, No. 2, No. 3, No. 7, and No. 14 were present, along with multiple double minutes. The possibility that the inherited partial trisomy No. 15 (and/or partial chromosome No. 13 monosomy) predisposed to neuroblastoma and additional chromosome changes in this tumor is discussed.