Details

Autor(en) / Beteiligte

• Tamiya, Hiroyuki
• Miyakawa, Megumi
• Suzuki, Hisanori
• Takeshita, Akira
• Ohashi, Kenichi
• Usui, Takeshi
• Miura, Daishu
• Takeuchi, Yasuhiro

Titel

A large functioning parathyroid cyst in a patient with multiple endocrine neoplasia type 1

Ist Teil von

• Endocrine Journal, 2013, Vol.60(6), pp.709-714

Ort / Verlag

Japan: The Japan Endocrine Society

Erscheinungsjahr

2013

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• A 62-year-old woman presented with a mass on the left side of the neck. Biochemical testing revealed primary hyperparathyroidism. Further, a prolactinoma was detected, and the patient’s son and daughter also had primary hyperparathyroidism, indicating that the patient had multiple endocrine neoplasia type 1 (MEN1). Neck ultrasonography revealed several cystic nodules (≤30 mm) that appeared to be adenomatous. After parathyroidectomy with autotransplantation, the largest cystic mass, in the left lower thyroid lobe, was pathologically diagnosed as a functioning parathyroid cyst, and all laboratory data returned to normal. On genetic analysis of blood, we found a novel single base insertion (duplication) in exon 10 codon 552 of the MEN1 gene (c1659dupT) that creates an early stop codon. This is the first case report of a parathyroid cyst resulting from parathyroid hyperplasia in a MEN1 patient.