Details

Autor(en) / Beteiligte

• Loyse, Angela
• Bicanic, Tihana
• Jarvis, Joseph N
• Day, Jeremy N
• Chau, Tran T.H
• Lalloo, David G

Titel

Combination Antifungal Therapy for Cryptococcal Meningitis

Ist Teil von

• The New England journal of medicine, 2013-06, Vol.368 (26), p.2522-2523

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2013

Quelle

Elektronische Zeitschriftenbibliothek - Freely accessible e-journals

Beschreibungen/Notizen

• To the Editor: In the trial of combination therapy for cryptococcal meningitis in patients with human immunodeficiency virus infection, Day et al. (April 4 issue) 1 found a survival benefit associated with 2 weeks of therapy with amphotericin B and flucytosine as compared with amphotericin B monotherapy. The results of this trial reinforce the treatment combination as the standard per current guidelines. 2 , 3 In locations where amphotericin B therapy is not feasible, flucytosine is recommended in combination with fluconazole. 2 – 4 However, the availability of flucytosine worldwide remains grossly inadequate. Flucytosine is currently unregistered and unavailable in most of Asia and Africa, . . .