Chemical communications (Cambridge, England), 2013-05, Vol.49 (39), p.4211-4213
2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Hydrometallation-asymmetric conjugate addition: application to complex molecule synthesis
- Ist Teil von
- Chemical communications (Cambridge, England), 2013-05, Vol.49 (39), p.4211-4213
- Ort / Verlag
- England
- Erscheinungsjahr
- 2013
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Copper catalysis allows alkyl zirconium species, generated in situ from alkenes, to undergo conjugate addition reactions. A hydrometallation-catalytic asymmetric 1,4-addition was used to synthesize either enantiomer of a natural product in one step from commercially available materials. Hydrometallation-addition sequences applied to steroids containing a cross-conjugated dienone or 1,6-acceptor give highly functionalized products.