Nature reviews. Neuroscience, 2013-06, Vol.14 (6), p.401-416
2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
- Ist Teil von
- Nature reviews. Neuroscience, 2013-06, Vol.14 (6), p.401-416
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2013
- Quelle
- EBSCOhost Psychology and Behavioral Sciences Collection
- Beschreibungen/Notizen
- Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of brain-derived neurotrophic factor (BDNF) in synaptic plasticity and synaptogenesis, the impact of the BDNF Val66Met polymorphism in Alzheimer's disease-relevant endophenotypes - including episodic memory and hippocampal volume - and the technological progress in measuring synaptic changes in humans all pave the way for a 'synaptic repair' therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis. This article reviews the key issues in translating BDNF biology into synaptic repair therapies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-003XeISSN: 1471-0048, 1469-3178DOI: 10.1038/nrn3505Titel-ID: cdi_proquest_miscellaneous_1372055882
- Format
- –
- Schlagworte
- Adaptation (Physiology), Alzheimer's disease, Animals, Biomarkers, Brain-derived neurotrophic factor, Brain-Derived Neurotrophic Factor - genetics, Brain-Derived Neurotrophic Factor - physiology, Brain-Derived Neurotrophic Factor - therapeutic use, Degeneration, Disease, Humans, Kinases, Molecular Targeted Therapy - methods, Nervous system, Neural transmission, Neurodegeneration, Neurodegenerative Diseases - drug therapy, Neurogenesis - genetics, Neurogenesis - physiology, Neuronal Plasticity - genetics, Neuronal Plasticity - physiology, Neurosciences, Pathogenesis, Pathophysiology, Physiological aspects, Polymorphism, Single Nucleotide - physiology, Receptor, trkB - agonists, Receptor, trkB - metabolism, Synapses - physiology