Details

Autor(en) / Beteiligte

• Lloyd, Clare M., PhD
• Saglani, Sejal, MD

Titel

T cells in asthma: Influences of genetics, environment, and T-cell plasticity

Ist Teil von

• Journal of allergy and clinical immunology, 2013-05, Vol.131 (5), p.1267-1274

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2013

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Asthma is classically considered the archetypal TH 2 disease, with increased circulating IgE levels and eosinophilic inflammation being caused by increased levels of TH 2-type cytokines. However, this paradigm has been challenged because of the realization that strategies designed to suppress TH 2 function are not effective for all patients. The clinical phenotype of asthma is notoriously heterogeneous and is affected by genetic and environmental exposures in addition to interactions between airway structural cells, including epithelial cells, and the immune system, as well as contributions from cells other than TH 2 cells. A combination of genetic and environmental factors is thought to influence whether inflammation resolves or progresses, and the pulmonary epithelium is increasingly recognized to play a key role in this process. This complex interplay has made it increasingly apparent that immune responses are tailored to the individual patient and determined by the weight of each influence, and thus the label of asthma as a TH 2 disease is too conservative. Indeed, an important concept that needs to be addressed, both in animal models and clinically, is that of T-cell plasticity and how lymphocytic responses are determined by environmental influences.