Annals of plastic surgery, 2013-07, Vol.71 (1), p.118-124
2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Preaxial Polydactyly of the Upper Limb Viewed as a Spectrum of Severity of Embryonic Events
- Ist Teil von
- Annals of plastic surgery, 2013-07, Vol.71 (1), p.118-124
- Ort / Verlag
- United States: Lippincott Williams & Wilkins, Inc
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- ABSTRACTPreaxial polydactyly (PPD) is a common congenital abnormality and its classification varies among geneticists and hand surgeons. For example, the triphalangeal thumb, preaxial polysyndactyly, and the mirror hand deformity are considered as forms of PPD only in the genetics literature. Preaxial polydactyly is an error in the anteroposterior axis of the development of the upper limb. In this paper, the development of this axis is detailed and all molecular events that are known to lead to PPD are reviewed. Finally, based on the review, PPD is viewed as a spectrum of severity of embryonic events.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0148-7043eISSN: 1536-3708DOI: 10.1097/SAP.0b013e318248b67fTitel-ID: cdi_proquest_miscellaneous_1370632707
- Format
- –
- Schlagworte
- Animals, Basic Helix-Loop-Helix Transcription Factors - genetics, Fibroblast Growth Factor 6 - genetics, Fingers - abnormalities, Fingers - embryology, Forearm - embryology, Gene Expression Regulation, Developmental - genetics, Gene Expression Regulation, Developmental - physiology, Genes, Homeobox - genetics, Genes, Homeobox - physiology, Hedgehog Proteins - genetics, Humans, Kruppel-Like Transcription Factors - genetics, Membrane Glycoproteins - genetics, Nerve Tissue Proteins - genetics, Nuclear Proteins - genetics, Polydactyly - embryology, Polydactyly - genetics, Transcription Factors - genetics, Twist-Related Protein 1 - genetics, Upper Extremity Deformities, Congenital - embryology, Zinc Finger Protein Gli3