Details

Autor(en) / Beteiligte

• Komada, Takanori
• Morishita, Yoshiyuki
• Kitamura, Masafumi
• Iwazu, Kana
• Numata, Akihiko
• Kobayashi, Takahisa
• Yamamoto, Hisashi
• Akimoto, Tetsu
• Saito, Osamu
• Ando, Yasuhiro
• Takemoto, Fumi
• Muto, Shigeaki
• Yumura, Wako
• Kusano, Eiji

Titel

Acute Kidney Injury in a Patient with Nephrotic Syndrome due to Focal Segmental Glomerular Nephritis Induced by a Single Oral Administration of High-dose Bisphosphonate (Minodronate)

Ist Teil von

• Internal Medicine, 2013, Vol.52(12), pp.1383-1387

Ort / Verlag

Japan: The Japanese Society of Internal Medicine

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We herein report the case of a 75-year-old man who developed an increased serum creatinine level (4.93 mg/dL) and oliguria with massive proteinuria (7.14 g/day) on the second day after a single oral administration of high-dose (56 mg) minodronate. The histology of a renal biopsy showed one area of glomerular sclerosis among 20 glomeruli with global foot process effacement of podocytes and mild infiltration of lymphocytes and eosinophils into the interstitial space. Acute kidney injury in nephrotic syndrome due to focal segmental glomerular sclerosis induced by minodronate was diagnosed. Following cessation of minodronate without the administration of immunosuppressive agents, the patient's renal function and proteinuria markedly improved.