Details

Autor(en) / Beteiligte

• Soulié, Cathia
• Lambert-Niclot, Sidonie
• Fofana, Djenaba Bocar
• Fourati, Slim
• Ait-Arkoub, Zaïna
• Sayon, Sophie
• Simon, Anne
• Katlama, Christine
• Calvez, Vincent
• Marcelin, Anne-Geneviève

Titel

Frequency of amino acid changes associated with resistance to attachment inhibitor BMS-626529 in R5- and X4-tropic HIV-1 subtype B

Ist Teil von

• Journal of antimicrobial chemotherapy, 2013-06, Vol.68 (6), p.1243-1245

Ort / Verlag

England: Oxford Publishing Limited (England)

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Resistance to attachment inhibitor BMS-626529, which inhibits the binding of HIV to CD4, involves mutations in the HIV-1 gp120 gene. There is a lack of information on the primary resistance of HIV-1 subtype B to attachment inhibitors, so we decided to investigate. Sequences from 109 attachment-inhibitor-naive patients infected with HIV-1 subtype B were analysed for the presence of previously described in vivo resistance mutations associated with attachment inhibitor BMS-626529 and tropism determination. The M426L substitution associated with a reduced efficacy of the attachment inhibitor BMS-626529 was present at 7.3%. There was no difference in mutation distribution according to virus tropism (R5 or X4). The attachment inhibitor BMS-626529 is suitable for most patients infected with HIV-1 subtype B.