Details

Autor(en) / Beteiligte

• Kim, Kyung-Yup
• Jang, Jae Young
• Kim, Jung-Wook
• Shim, Jae-Jun
• Lee, Chang Kyun
• Dong, Seok Ho
• Kim, Hyo Jong
• Kim, Byung-Ho
• Chang, Young Woon

Titel

Acid Suppression Therapy as a Risk Factor for Candida Esophagitis

Ist Teil von

• Digestive diseases and sciences, 2013-05, Vol.58 (5), p.1282-1286

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Background/Aim As the prevalence of reflux esophagitis increases, so does the use of gastric acid suppressants. This study aimed to document the prevalence of Candida esophagitis (CE) at a single Korean university hospital over the last 5 years and to evaluate its risk factors. Methods To investigate the prevalence of CE, we conducted a retrospective analysis of 55,314 individuals who underwent a screening esophagogastroduodenoscopy as part of a health check-up between January 2006 and December 2010 at Kyung Hee University Hospital in Seoul, Korea. A total of 250 patients who were treated for CE between January 2008 and August 2011 and 500 age- and sex-matched non-CE patients were enrolled in this study. The rates of recent gastric acid suppression therapy and other well-known risk factors in the two groups were compared. Results The prevalence of CE was 0.35 % and increased each year (linear-by-linear association, P  = 0.001). Univariate analysis showed that gastric acid suppression therapy, malignancy, DM and steroid therapy were related to CE. Multivariate analysis also showed that gastric acid suppression therapy (OR 5.11, 95 % CI 2.92–8.93 and P  < 0.001), malignancy (OR 18.68, 95 % CI 6.37–54.75 and P  < 0.001), DM (OR 2.67, 95 % CI 1.70–4.21 and P  < 0.001) and steroids therapy (OR 6.74, 95 % CI 1.37–33.05 and P  = 0.019) were related to CE. Conclusions The prevalence of CE in Korea is increasing. Also, our results indicate that acid suppression therapy is a meaningful risk factor for CE.