Details

Autor(en) / Beteiligte

• Illés, Erzsébet
• Takács, Erzsébet
• Dombi, András
• Gajda-Schrantz, Krisztina
• Gonter, Katalin
• Wojnárovits, László

Titel

Radiation induced degradation of ketoprofen in dilute aqueous solution

Ist Teil von

• Radiation physics and chemistry (Oxford, England : 1993), 2012-09, Vol.81 (9), p.1479-1483

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2012

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The intermediates and final products of ketoprofen degradation were investigated in 0.4mmoldm−3 solution by pulse radiolysis and gamma radiolysis. For observation of final products UV−vis spectrophotometry and HPLC separation with diode array detection were used, and for identification MS was used. The reactions of •OH lead to hydroxycyclohexadienyl type radical intermediates, in their further reactions hydroxylated derivatives of ketoprofen form as final products. The hydrated electron is scavenged by the carbonyl oxygen and the electron adduct protonates to ketyl radical •OH is more effective in decomposing ketoprofen than hydrated electron. Chemical oxygen demand and total organic carbon content measurements on irradiated aerated solutions showed that using irradiation technology ketoprofen can be mineralised. The initial toxicity of the solution monitored by the Daphnia magna test steadily decreases with irradiation. Using 5kGy dose no toxicity of the solution was detected with this test. ► In •OH reactions hydroxylated derivatives of ketoprofen form as stable products. ► •OH is more effective in decomposing ketoprofen than hydrated electron. ► Toxicity of the ketoprofen solution decreases with irradiation.