International journal of urology, 2013-06, Vol.20 (6), p.637-639
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Presurgical downstaging of vena caval tumor thrombus in advanced clear cell renal cell carcinoma using temsirolimus
- Ist Teil von
- International journal of urology, 2013-06, Vol.20 (6), p.637-639
- Ort / Verlag
- Australia
- Erscheinungsjahr
- 2013
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- : A 63‐year‐old man presenting with a 7.2‐cm right renal mass, an inferior vena cava tumor thrombus, and pulmonary metastases underwent renal mass biopsy that revealed clear cell renal cell carcinoma. Temsirolimus (25 mg weekly) was given because of the extent of the disease and poor performance status, which resulted in a marked reduction in the tumor thrombus (from level III to level I) after 20 weeks of treatment. Subsequently, radical nephrectomy and tumor thrombectomy were carried out. Final pathological analysis confirmed the diagnosis of high‐grade clear cell carcinoma (pT4N0M1). One year after initiation of temsirolimus therapy, the patient remained alive despite the presence of disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0919-8172eISSN: 1442-2042DOI: 10.1111/iju.12012Titel-ID: cdi_proquest_miscellaneous_1364708919
- Format
- –
- Schlagworte
- Adenocarcinoma, Clear Cell - drug therapy, Adenocarcinoma, Clear Cell - pathology, Antineoplastic Agents - therapeutic use, Carcinoma, Renal Cell - drug therapy, Carcinoma, Renal Cell - pathology, Humans, Kidney Neoplasms - drug therapy, Kidney Neoplasms - pathology, Male, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, presurgical setting, renal cancer, Sirolimus - analogs & derivatives, Sirolimus - therapeutic use, temsirolimus, Thrombosis - etiology, Thrombosis - pathology, tumor thrombus, Vena Cava, Inferior - pathology