Details

Autor(en) / Beteiligte

• Leygue, Etienne
• Murphy, Leigh C

Titel

A bi-faceted role of estrogen receptor β in breast cancer

Ist Teil von

• Endocrine-related cancer, 2013-06, Vol.20 (3), p.R127-R139

Ort / Verlag

England: Society for Endocrinology

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Despite over 15 years of research, the exact role, if any, played by estrogen receptor β (ERβ) in human breast cancer remains elusive. A large body of data both in vitro and in vivo supports its role as an antiproliferative, pro-apoptotic factor especially when co-expressed with ERα. However, there is a smaller body of data associating ERβ with growth and survival in breast cancer. In clinical studies and most often in cell culture studies, the pro-growth and pro-survival activity of ERβ occurs in ERα-negative breast cancer tissue and cells. This bi-faceted role of ERβ is discussed in this review.