Nanomedicine (London, England), 2013-03, Vol.8 (3), p.379-388
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Fluorescent nanothermometers provide controlled plasmonic-mediated intracellular hyperthermia
- Ist Teil von
- Nanomedicine (London, England), 2013-03, Vol.8 (3), p.379-388
- Ort / Verlag
- London: Future Medicine Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- This article demonstrates how controlled hyperthermia at the cellular level can be achieved. The method is based on the simultaneous intracellular incorporation of fluorescence nanothermometers (CdSe quantum dots) and metallic nanoheaters (gold nanorods). Real-time spectral analysis of the quantum dot emission provides a detailed feedback about the intracellular thermal loading caused by gold nanorods excited at the plasmon frequency. Based on this approach, thermal dosimetry is assessed in such a way that the infrared laser (heating) power required to achieve catastrophic intracellular temperature increments in cancer cells is identified. This pure optical method emerges as a new and promising guide for the development of infrared hyperthermia therapies with minimal invasiveness. Original submitted 6 March 2012; Revised submitted 3 July 2012; Published online 2 December 2012
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1743-5889eISSN: 1748-6963DOI: 10.2217/nnm.12.122Titel-ID: cdi_proquest_miscellaneous_1352293311
- Format
- –
- Schlagworte
- Biological and medical sciences, Cadmium Compounds - chemistry, cancer therapy, Cell Physiological Phenomena, Cellular control mechanisms, Fever, Fluorescence, Gold - chemistry, HeLa Cells, Humans, Hyperthermia, Induced hyperthermia. Cryotherapy, Innovations, laser thermal effect, Medical sciences, Medical thermometers, metallic nanoheaters, Nanotechnology, nanothermometers, Nanotubes - chemistry, Observations, Physiological aspects, Quantum Dots, Selenium Compounds - chemistry, Thermometers, Treatment with physical agents, Treatment. General aspects, Tumors