Clinical lymphoma, myeloma and leukemia, 2013-04, Vol.13 (2), p.211-213
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Immunoglobulin M Concentration in Waldenström Macroglobulinemia: Correlation With Bone Marrow B Cells and Plasma Cells
- Ist Teil von
- Clinical lymphoma, myeloma and leukemia, 2013-04, Vol.13 (2), p.211-213
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Serum immunoglobulin (Ig) M levels vary considerably among patients with Waldenström macroglobulinemia, and previous studies have failed to demonstrate a correlation with overall bone marrow disease burden. In this study, bone marrow B cells and plasma cells were enumerated by flow cytometry and correlated with serum IgM concentrations. Monotypic B cells comprised a median of 6% of bone marrow leukocytes but did not correlate with IgM levels ( r = 0.071, P = .5). Plasma cells, although typically present in lower numbers (median, 0.52%) did show a correlation with IgM ( r = 0.452, P = .01). IgM levels in Waldenström macroglobulinemia, at least in part, correlate with the degree of plasma cell differentiation seen within the tumor.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2152-2650eISSN: 2152-2669DOI: 10.1016/j.clml.2013.02.018Titel-ID: cdi_proquest_miscellaneous_1350892390
- Format
- –
- Schlagworte
- Adult, Aged, Aged, 80 and over, B-Lymphocytes - metabolism, B-Lymphocytes - pathology, Biopsy, Bone Marrow - pathology, Bone Marrow Cells - metabolism, Bone Marrow Cells - pathology, Female, Hematology, Oncology and Palliative Medicine, Humans, Immunoglobulin M, Immunoglobulin M - blood, Male, Middle Aged, Plasma cell, Plasma Cells - metabolism, Plasma Cells - pathology, Waldenstrom Macroglobulinemia - blood, Waldenstrom Macroglobulinemia - metabolism, Waldenström macroglobulinemia