Details

Autor(en) / Beteiligte

• Stanworth, Simon J
• Estcourt, Lise J
• Powter, Gillian
• Kahan, Brennan C
• Dyer, Claire
• Choo, Louise
• Bakrania, Lekha
• Llewelyn, Charlotte
• Littlewood, Timothy
• Soutar, Richard
• Norfolk, Derek
• Copplestone, Adrian
• Smith, Neil
• Kerr, Paul
• Jones, Gail
• Raj, Kavita
• Westerman, David A
• Szer, Jeffrey
• Jackson, Nicholas
• Bardy, Peter G
• Plews, Dianne
• Lyons, Simon
• Bielby, Linley
• Wood, Erica M
• Murphy, Michael F

Titel

A No-Prophylaxis Platelet-Transfusion Strategy for Hematologic Cancers

Ist Teil von

• The New England journal of medicine, 2013-05, Vol.368 (19), p.1771-1780

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Prophylactic platelet transfusions for patients with platelet counts of less than 10,000 per cubic millimeter reduced the rate of WHO grade 2, 3, or 4 bleeding events and the number of days with bleeding, as compared with patients who did not receive transfusions. In patients with hematologic cancers, severe thrombocytopenia frequently develops as a consequence of the disease or its treatment. Most platelet transfusions are administered as prophylaxis, to increase low platelet counts and reduce the risk of bleeding. 1 However, the degree to which prophylactic platelet transfusions benefit patients with severe thrombocytopenia has been unclear. 2 – 4 A recent trial suggested that a policy of giving platelet transfusions only as treatment for bleeding might become a new standard of care in selected patients, 5 although the primary end point was a reduction in the number of platelet transfusions, not a clinical outcome such as bleeding. . . .