Vaccine, 2012-07, Vol.30 (34), p.5159-5171
2012
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- Autor(en) / Beteiligte
- Titel
- Two live attenuated Shigella flexneri 2a strains WRSf2G12 and WRSf2G15: A new combination of gene deletions for 2nd generation live attenuated vaccine candidates
- Ist Teil von
- Vaccine, 2012-07, Vol.30 (34), p.5159-5171
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- ScienceDirect
- Beschreibungen/Notizen
- Highlights ► New, second-generation live attenuated Shigella flexneri 2a vaccine candidates. ► WRSf2G12 and WRSf2G15 are as invasive as parental strain 2457T in HeLa cells. ► WRSf2G12 and WRSf2G15 are Sereny negative and protective in guinea pigs. ► WRSf2G15 that lacks the MsbB2 gene has lower endotoxicity profile in macrophages. ► A 3 vs. 2 dose immunization regimen provides better protection in guinea pigs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2012.05.003Titel-ID: cdi_proquest_miscellaneous_1348489951
- Format
- –
- Schlagworte
- Allergy and Immunology, animal models, Animals, Antibodies, Bacterial - immunology, Bacterial Proteins - genetics, Bacterial Proteins - immunology, Bacterial Proteins - metabolism, cell culture, clinical trials, Disease Models, Animal, Drug Stability, dysentery, Dysentery, Bacillary - immunology, Dysentery, Bacillary - microbiology, Dysentery, Bacillary - therapy, Gene Deletion, genes, Genes, Bacterial, Guinea Pigs, HeLa Cells, Humans, Immunity, Mucosal, immunization, Immunization Schedule, Live Shigella vaccine, Macrophages - immunology, Macrophages - microbiology, Mice, mucosal immunity, S. flexneri 2a vaccine, Shigella flexneri, Shigella flexneri - genetics, Shigella flexneri - immunology, Shigella flexneri - pathogenicity, Shigella Vaccines - administration & dosage, Shigella Vaccines - genetics, Shigella Vaccines - immunology, vaccine development, vaccines, Vaccines, Attenuated - administration & dosage, Vaccines, Attenuated - genetics, Vaccines, Attenuated - immunology, Vaccines, Synthetic - administration & dosage, Vaccines, Synthetic - genetics, Vaccines, Synthetic - immunology, WRSf2G12 and WRSf2G15