Details

Autor(en) / Beteiligte

• Smith, Duncan RM
• Grüschow, Sabine
• Goss, Rebecca JM

Titel

Scope and potential of halogenases in biosynthetic applications

Ist Teil von

• Current opinion in chemical biology, 2013-04, Vol.17 (2), p.276-283

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• ► Halogenated natural products are diverse in structure, activity, and biosynthesis. ► Halogenases can show high regioselectivity that is often difficult to achieve synthetically. ► Chlorine and bromine can be installed at a wide range of chemical functionalities. ► Developing halogenases through enzyme engineering is an emerging area of study. ► Enzymes acting late in biosynthesis hold intriguing potential for synthesis. A large and diverse series of halogenated natural products exist. In many of these compounds the halogen is important to biological activity and bioavailability. We now recognise that nature has developed many different halogenation strategies for which well-known enzyme classes such as haem oxidases or flavin-dependent oxidases have been adapted. Enzymes capable of halogenating all kinds of different chemical groups from electron-rich to electron-poor, from aromatic to aliphatic have been characterised. Given that synthetic halogenation reactions are not trivial transformations and that halogenated molecules possess pharmaceutical usefulness, it will be worth investing into further research of halogenating enzymes.