Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (10), p.2955-2961
- Mitton-Fry, Mark J.
- Brickner, Steven J.
- Hamel, Judith C.
- Brennan, Lori
- Casavant, Jeffrey M.
- Chen, Michael
- Chen, Tao
- Ding, Xiaoyuan
- Driscoll, James
- Hardink, Joel
- Hoang, Thuy
- Hua, Erbing
- Huband, Michael D.
- Maloney, Meghan
- Marfat, Anthony
- McCurdy, Sandra P.
- McLeod, Dale
- Plotkin, Michael
- Reilly, Usa
- Robinson, Shaughn
- Schafer, John
- Shepard, Richard M.
- Smith, James F.
- Stone, Gregory G.
- Subramanyam, Chakrapani
- Yoon, Kwansik
- Yuan, Wei
- Zaniewski, Richard P.
- Zook, Christopher
2013
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- Autor(en) / Beteiligte
- Mitton-Fry, Mark J.
- Brickner, Steven J.
- Hamel, Judith C.
- Brennan, Lori
- Casavant, Jeffrey M.
- Chen, Michael
- Chen, Tao
- Ding, Xiaoyuan
- Driscoll, James
- Hardink, Joel
- Hoang, Thuy
- Hua, Erbing
- Huband, Michael D.
- Maloney, Meghan
- Marfat, Anthony
- McCurdy, Sandra P.
- McLeod, Dale
- Plotkin, Michael
- Reilly, Usa
- Robinson, Shaughn
- Schafer, John
- Shepard, Richard M.
- Smith, James F.
- Stone, Gregory G.
- Subramanyam, Chakrapani
- Yoon, Kwansik
- Yuan, Wei
- Zaniewski, Richard P.
- Zook, Christopher
- Titel
- Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (10), p.2955-2961
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2013.03.047Titel-ID: cdi_proquest_miscellaneous_1345510439
- Format
- –
- Schlagworte
- Animals, Anti-Bacterial Agents - administration & dosage, Anti-Bacterial Agents - chemistry, Anti-Bacterial Agents - pharmacology, Antibacterial, antibacterial properties, chemistry, DNA gyrase, DNA Gyrase - metabolism, DNA topoisomerase (ATP-hydrolysing), DNA Topoisomerase IV - antagonists & inhibitors, DNA Topoisomerase IV - metabolism, DNA Topoisomerases, Type II - metabolism, Dose-Response Relationship, Drug, Dual-targeting, Enzyme Inhibitors - administration & dosage, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, Ether-A-Go-Go Potassium Channels - antagonists & inhibitors, Humans, Inhibitor, Microbial Sensitivity Tests, Molecular Structure, pharmacokinetics, quinoline, Quinolines - administration & dosage, Quinolines - chemistry, Quinolines - pharmacology, Rats, Staphylococcus aureus - drug effects, Staphylococcus aureus - enzymology, Streptococcus pneumoniae - drug effects, Streptococcus pneumoniae - enzymology, Structure-Activity Relationship, Topoisomerase II Inhibitors, Topoisomerase IV