Details

Autor(en) / Beteiligte

• Crick, F.H.C.
• Wyman, Jeffries

Titel

A Footnote on Allostery

Ist Teil von

• Journal of molecular biology, 2013-05, Vol.425 (9), p.1500-1508

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A manuscript on allostery signed by Francis Crick and Jeffries Wyman was sent by Crick to Jacques Monod in 1965. Monod transmitted a copy of the manuscript, upon which he had written several comments, to Jean-Pierre Changeux, then a post-doctoral fellow at the University of California Berkeley in the laboratory of Howard Schachman. Changeux provided a copy to Stuart Edelstein, a graduate student in the same laboratory. The manuscript was never submitted for publication, but Edelstein retained his copy since that time and has edited it for publication in the special issue on allostery. The text emphasized the interpretation of the properties of an allosteric oligomer by characterizing its equivalent monomer. The text also developed the concept of the allosteric range and included a simple equation for calculation of the Hill coefficient from the parameters of the Monod-Wyman-Changeux model. [Display omitted] ► The interesting text on allostery written in 1965 by Francis Crick and Jeffries Wyman is published for the first time. ► Text presents several novel relationships for allosteric proteins such as the allosteric range and the equivalent monomer. ► A very simple equation is presented to calculate the Hill coefficient. ► This text combines a novel and thorough examination of allosteric principles that is of exceptional historical interest.