Trends in immunology, 2012-12, Vol.33 (12), p.633-640
2012
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- Autor(en) / Beteiligte
- Titel
- High-mobility group box family of proteins: ligand and sensor for innate immunity
- Ist Teil von
- Trends in immunology, 2012-12, Vol.33 (12), p.633-640
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Recent discoveries in signal-transducing innate receptors have illustrated the close link between innate and adaptive immunity. These advances revisit a fundamental issue of immunology, the recognition of self and non-self molecules by the immune system. Indeed, mounting evidence has been provided that the sensing of self-derived molecules by the immune system is important for health and disease. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived immune activators that have multiple functions in the regulation of immunity and inflammation. In this review, we summarize current knowledge of the function of HMGB proteins, as a ligand that can evoke inflammatory responses, and as a sensor for nucleic-acid-mediated immune responses.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-4906eISSN: 1471-4981DOI: 10.1016/j.it.2012.10.005Titel-ID: cdi_proquest_miscellaneous_1328509090
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Cytokines, Cytokines - immunology, DAMPs, Deoxyribonucleic acid, Disease, DNA, DNA repair, HMGB proteins, HMGB Proteins - immunology, Homeostasis, Humans, Immune system, Immunity, Innate, inflammation, innate immunity, Ligands, Mammals, nucleic acids, Proteins, PRRs, Rodents, Science, Signal Transduction, Technological change, Toll-Like Receptors - immunology