Details

Autor(en) / Beteiligte

• Ypsilantis, Petros
• Lambropoulou, Maria
• Anagnostopoulos, Constantinos
• Tsigalou, Christina
• Vasiliadis, Constantinos
• Kortsaris, Alexandros
• Papadopoulos, Nikolaos
• Simopoulos, Constantinos

Titel

Pringle maneuver exacerbates systemic inflammatory response and multiple-organ injury induced by extended liver radiofrequency ablation

Ist Teil von

• Human & Experimental Toxicology, 2011-11, Vol.30 (11), p.1855-1864

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Aim: To assess the systemic inflammatory response (SIR) and the multi-organ damage after large-volume liver radiofrequency ablation (RFA) with or without concurrent Pringle maneuver. Methods: Wistar rats were subjected to 30% liver RFA (group RFA), liver RFA under 30-min Pringle maneuver (group RFA + P), Pringle only (group P) or sham operation (group S). Serum levels of interleukin-1α (IL-1α), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), serum biochemical profile, multiple-organ pathology and the activity of nuclear factor-κB (NF-κB) in the liver were assessed post-operatively. Results: The levels of IL-6 and TNF-α were increased from 1h up to 1w and 6h, respectively, in both RFA groups, while IL-6 was only mildly increased at 3 h in group P. IL-6 was higher in group RFA + P compared to group RFA. Serum biochemical profile was altered more intensely in group RFA + P compared to RFA. There was tissue injury in the non-ablated liver portion as well as in adjacent and remote organs with lesions being more severe in group RFA + P. At 1 h, NF-κB was equally activated in all study groups. Conclusions: Extended liver RFA causes SIR and multi-organ injury, which are exacerbated when a concurrent Pringle maneuver is applied.