Details

Autor(en) / Beteiligte

• Desai, Nisheeth C.
• Rajpara, Kiran M.
• Joshi, Vivek V.

Titel

Synthesis of pyrazole encompassing 2-pyridone derivatives as antibacterial agents

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (9), p.2714-2717

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2013

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• A series of 6-amino-1-((1,3-diphenyl-1H-pyrazole-4-yl)methyleneamino)-4-(aryl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles (4a–t) have been prepared and screened for in vitro antibacterial activity. A series of novel compounds 6-amino-1-((1,3-diphenyl-1H-pyrazole-4-yl)methyleneamino)-4-(aryl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles (4a–t) were synthesized and characterized by IR, 1H NMR, 13C NMR and mass spectral data. These compounds were screened for their in vitro antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes (Gram positive), Escherichia coli, Pseudomonas aeruginosa (Gram negative) by serial broth dilution and cytotoxic activity (NIH 3T3 & HeLa) by MTT assay. The results indicated that compounds 4g, 4i, 4m, 4o, 4r and 4t exhibit potent antibacterial activity against bacterial strains at non-cytotoxic concentrations.