Details

Autor(en) / Beteiligte

• Gilglioni, Eduardo Hideo
• Campos, Lilian Brites
• Oliveira, Monique Cristine
• Garcia, Rosângela Fernandes
• Ambiel, Célia Regina
• Buzzo, Ana Julia dos Reis
• Ishii-Iwamoto, Emy Luzia
• Salgueiro-Pagadigorria, Clairce Luzia

Titel

Beneficial effects of tibolone on blood pressure and liver redox status in ovariectomized rats with renovascular hypertension

Ist Teil von

• The journals of gerontology. Series A, Biological sciences and medical sciences, 2013-05, Vol.68 (5), p.510-520

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2013

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Estrogen deficiency is associated with aging and increases the incidence of metabolic syndrome and hypertension. In this study, the effects of tibolone, a synthetic steroid, on the cardiovascular system, liver lipid metabolism, and redox status were evaluated, in ovariectomized (OVX) rats with renovascular hypertension (two-kidneys, one-clip, OVX + 2K1C). This study encompassed direct measurements of mean arterial pressure , plasma biochemical analysis, liver lipid contents, and assessments of the mitochondrial and peroxisomal β-oxidation capacities. Additionally, the liver redox status was assayed. Tibolone significantly reduced the mean arterial pressure of OVX + 2K1C rats, albeit reducing total and high-density lipoprotein (HDL) cholesterol levels. In the liver, although exerting an undesirable inhibition of mitochondrial and peroxisomal β-oxidation, tibolone reversed steatosis. Tibolone also improved the liver redox status: the reduced glutathione contents and the activity of glucose-6-phosphate dehydrogenase were restored by this compound, which also reduced the levels of thiobarbituric acid-reactive substances and the generation of mitochondrial reactive oxygen species. So, tibolone reversed the main alterations caused by hypertension and estrogen deficiency.