European journal of medicinal chemistry, 2013-04, Vol.62, p.206-213
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide
- Ist Teil von
- European journal of medicinal chemistry, 2013-04, Vol.62, p.206-213
- Ort / Verlag
- France
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Fructus gardeniae has long been used by traditional Chinese medical practitioners for its anti-inflammatory, anti-oxidant, anti-tumor and anti-hyperlipidemic characteristics. Here we describe our finding that F. gardeniae greatly reduces anti-enterovirus 71 (EV71) activity, resulting in significant decreases in EV71 virus yields, EV71 infections, and internal ribosome entry site activity. We also found that geniposide, a primary F. gardeniae component, inhibited both EV71 replication and viral IRES activity. Our data suggest the presence of a mechanism that blocks viral protein translation. According to our findings, F. gardeniae and geniposide deserve a closer look as potential chemopreventive agents against EV71 infections.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0223-5234eISSN: 1768-3254DOI: 10.1016/j.ejmech.2012.12.038Titel-ID: cdi_proquest_miscellaneous_1325331722
- Format
- –
- Schlagworte
- Antiviral Agents - chemistry, Antiviral Agents - pharmacology, Cell Line, Tumor, Drugs, Chinese Herbal - chemistry, Drugs, Chinese Herbal - pharmacology, Enterovirus A, Human - drug effects, Enterovirus Infections - drug therapy, Enterovirus Infections - virology, Gardenia - chemistry, Humans, Iridoids - chemistry, Iridoids - pharmacology, Medicine, Chinese Traditional, Microbial Sensitivity Tests, Molecular Sequence Data, Protein Biosynthesis - drug effects, Protein Biosynthesis - genetics, Ribosomes - metabolism, RNA, Viral - genetics, RNA, Viral - metabolism, Virus Replication - drug effects