Cancer research (Chicago, Ill.), 2013-04, Vol.73 (7), p.2322-2332
2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer
- Ist Teil von
- Cancer research (Chicago, Ill.), 2013-04, Vol.73 (7), p.2322-2332
- Ort / Verlag
- Philadelphia, PA: American Association for Cancer Research
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely as a specific subpopulation of cells needed for cancer initiation and progression. TICs have yet to be identified in esophageal tumors that have an increasing incidence in developed countries. Here, we report a CD90(+) cell population found in esophageal squamous cell carcinoma (ESCC), which is endowed with stem cell-like properties and high tumorigenic and metastatic potential. mRNA profiling of these cells suggested pathways through which they drive tumor growth and metastasis, with deregulation of an Ets-1/MMP signaling pathway and epithelial-mesenchymal transition figuring prominently. These cells possessed higher self-renewal activity and were sufficient for tumor growth, differentiation, metastasis, and chemotherapeutic resistance. CD90(+) TICs were isolated and characterized from ESCC clinical specimens as well as ESCC cell lines. In freshly resected clinical specimens, they represented a rare cell population, the levels of which correlated with strong family histories and lymph node metastasis. Our results prompt further study of this CD90(+) population of esophageal TICs as potential therapeutic targets.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0008-5472eISSN: 1538-7445DOI: 10.1158/0008-5472.CAN-12-2991Titel-ID: cdi_proquest_miscellaneous_1324387347
- Format
- –
- Schlagworte
- Animals, Antineoplastic agents, Apoptosis, Biological and medical sciences, Biomarkers, Tumor - genetics, Biomarkers, Tumor - metabolism, Blotting, Western, Carcinoma, Squamous Cell - genetics, Carcinoma, Squamous Cell - metabolism, Carcinoma, Squamous Cell - secondary, Cell Adhesion, Cell Differentiation, Cell Movement, Cell Proliferation, Disease Progression, Epithelial-Mesenchymal Transition, Esophageal Neoplasms - genetics, Esophageal Neoplasms - metabolism, Esophageal Neoplasms - pathology, Esophagus, Female, Flow Cytometry, Gastroenterology. Liver. Pancreas. Abdomen, Gene Expression Profiling, Humans, Immunoenzyme Techniques, Liver Neoplasms, Experimental - genetics, Liver Neoplasms, Experimental - metabolism, Liver Neoplasms, Experimental - secondary, Lung Neoplasms - genetics, Lung Neoplasms - metabolism, Lung Neoplasms - secondary, Lymphatic Metastasis, Male, Medical sciences, Mice, Mice, Inbred NOD, Mice, SCID, Middle Aged, Multiple tumors. Solid tumors. Tumors in childhood (general aspects), Neoplasm Staging, Neoplastic Stem Cells - metabolism, Neoplastic Stem Cells - pathology, Pharmacology. Drug treatments, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger - genetics, RNA, Small Interfering - genetics, Signal Transduction, Thy-1 Antigens - chemistry, Thy-1 Antigens - genetics, Thy-1 Antigens - metabolism, Tumors