Details

Autor(en) / Beteiligte

• Ting-A-Kee, Ryan
• Vargas-Perez, Hector
• Bufalino, Mary-Rose
• Bahi, Amine
• Dreyer, Jean-Luc
• Tyndale, Rachel F.
• van der Kooy, Derek

Titel

Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation

Ist Teil von

• The European journal of neuroscience, 2013-03, Vol.37 (6), p.996-1003

Ort / Verlag

Oxford: Blackwell Publishing Ltd

Erscheinungsjahr

2013

Quelle

PBSC : Psychology and Behavioral Sciences Collection - Journals

Beschreibungen/Notizen

• Recent work has shown that infusion of brain‐derived neurotrophic factor (BDNF) into the ventral tegmental area (VTA) promotes a switch in the mechanisms mediating morphine motivation, from a dopamine‐independent to a dopamine‐dependent pathway. Here we showed that a single infusion of intra‐VTA BDNF also promoted a switch in the mechanisms mediating ethanol motivation, from a dopamine‐dependent to a dopamine‐independent pathway (exactly opposite to that seen with morphine). We suggest that intra‐VTA BDNF, via its actions on TrkB receptors, precipitates a switch similar to that which occurs naturally when mice transit from a drug‐naive, non‐deprived state to a drug‐deprived state. The opposite switching of the mechanisms underlying morphine and ethanol motivation by BDNF in previously non‐deprived animals is consistent with their proposed actions on VTA GABAA receptors. Recent work has shown that infusion of brain‐derived neurotrophic factor (BDNF) into the ventral tegmental area (VTA) promotes a switch in the mechanisms mediating morphine motivation, from a dopamine‐independent to a dopamine‐dependent pathway. Here we show that a single infusion of intra‐VTA BDNF also promotes a switch in the mechanisms mediating ethanol motivation, from a dopamine‐dependent to a dopamine‐independent pathway — exactly opposite to that seen with morphine.